Esketamine Treatment-Resistant Depression

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Esketamine Treatment-Resistant Depression

At Sage Clinics, we understand the challenges that come with treatment-resistant depression (TRD). Traditional antidepressants can take weeks to start working, and even then, they may not be effective for everyone. That’s why we offer esketamine treatment, a fast-acting and innovative option for those struggling with TRD.

Esketamine is a type of ketamine that is administered through a nasal spray. Unlike traditional antidepressants, which can take weeks to start working, esketamine is fast-acting and can bring relief within hours or days. It works by targeting the brain’s glutamate system, which is believed to be involved in depression. However, while esketamine has been shown to be effective for some people with TRD, it is not a first-line treatment and is generally reserved for those who have not responded to other antidepressants.

The process for esketamine treatment typically involves several steps and is closely monitored by mental health professionals. Here’s what you can expect during the treatment process:

  • Initial Consultation: The first step is to schedule an initial consultation with one of our Consultant Psychiatrist. During this consultation, our experienced psychiatrist will assess your symptoms, medical history, and current medications to determine if esketamine treatment is right for you. They will also explain the treatment process and answer any questions or concerns you may have.
  • Treatment Sessions: Esketamine is administered through a nasal spray, and the treatment sessions take place in our clinic. During the treatment session, you will be seated in a comfortable chair or couch, and the treating professional will demonstrate how to self-administer the nasal spray. The dosage and frequency of the treatment will vary depending on your individual needs and treatment plan, but the first few treatments are usually given twice a week for several weeks, followed by a maintenance phase where treatments are given less frequently.
  • Post-treatment monitoring: After each treatment session, you will be closely monitored by a healthcare professional for at least 60-90 minutes. This is to ensure that you are not experiencing any adverse side effects and to assess the effectiveness of the treatment.
  • Follow-up appointments: After the initial treatment phase, you will have follow-up appointments with our psychiatrist to monitor your progress and adjust your treatment plan as needed. The frequency of these appointments will vary depending on your individual needs.

It is important to note that esketamine treatment is not a one-size-fits-all solution, and the treatment process may vary depending on your individual needs and treatment plan. Our experienced professionals will work closely with you to develop a treatment plan that meets your unique needs and goals.

We understand that seeking treatment for TRD can be daunting, but our team is here to support you every step of the way. We are committed to helping you find relief from your symptoms and improving your overall quality of life. Sage provides a safe and comfortable environment for your esketamine treatment sessions. We prioritize your comfort and safety throughout the treatment process, and our healthcare professionals are available to answer any questions or concerns you may have.

Who can benefit from it?

Any individuals who are struggling with depression and have not responded to other antidepressants.

Private: Dr Zeeshan Ahmad Consultant Psychiatrist, Adults Specialist

I am a General Adult Consultant Psychiatrist with over 10 years of experience...

Everyone deserves Our special care

How it works

We know it’s likely to have been a struggle to get this far, but we are with you every step of the way. Our process is simple – we work with you to develop a unique plan and provide the a level of support according to your needs, whilst ensuring measurable and sustainable outcomes.


Book an appointment by calling us on +971 4 575 5684 (or you can book online) and tell us what you are having difficulty with.


We offer availability with highly experienced therapists suited to your needs and book the appointment for you.


Meet the practitioner and begin the road to self-improvement. Have any concerns? Let us know so we can assist.


We always care about
your mental health

Our goal is to support individuals, couples, families and groups experiencing challenges with mental, behavioral or emotional wellbeing to overcome these challenges, learn new skills, and thrive at life.